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KMID : 0385019970130020191
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Korean Journal of Laboratory Animal Science
1997 Volume.13 No. 2 p.191 ~ p.194
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Subcutaneous Implantation Test of self-curing resins in Guinea Pigs
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이선희/Lee, Sun Hee
이종권/이영순/김대병/김부영/류승렬/Lee, Jong Kwon/Lee, Yong Soon/Kim, Dai Byung/Kim, Pu Young/Ryu, Seung Rel
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Abstract
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In order to develop the test method of safety evaluation of dental materials, subcutaneous implantation test was carried out with using 2 self-curing resins in guinea pigs. Autopolymerization resins were inserted into Teflon^ⓡ tube(10㎜ long, 1.3㎜ inner diameter) respectively and implanted in dorsal subcutaneous tissue of guinea pigs under pentobarbital sodium anesthesia. Each animsil received four implante. The implants were left in place for 2 weeks and 12 weeks. The tissue along the- mid section of the Teflon^ⓡ tube serves as a control. There were no significant differences in mean body weight changes in guinea pip during the feet period. Any particular changes in clinical sites were not observed in animals implanted for both 2 and 12 weeks. Any significant changes in guinea pigs implanted for 2 and 12 weeks were not observed at autopsy. The tissue of animals for 2 and 12 weeks was well organized with no more inflammatory reaction where the tissue had been exposed to the resin at the ends: of the tube than along its mid section. Any significant changes between control site and resin exposed site were not observed in animals implanted for both 2 and 12 weeks histopathologically.
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